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The interaction of salicylic acid (S.A), salicylamide (S.M) with nucleic acid base derivatives such as 9-ethyl adenine (A), 1-cyclohexyl uracil (U). 2’’, 3’’-Lenzylidine-5’’ trityl-cytidine (C), guanosine-2’’, 3’’, 5’’-isobutylate (G) has been spectroscopically investigated to determine the binding mechanism. NIMR and IR spectra were measured in nonpolar solvents. The association constant K of the formation of complex was calculated from the 1R spectra. Compounds S.A and A form a 1 : 1 or 1 : 2 cyclic hydrogen-bonded complex depending on the simple concentration. Compounds S.A and U form a 1 : 1 or 1 : 2 hydrogen-bonded complex on the simple concentration. Compounds S.A and C form a 2 : 1 hydrogen bonded complex at low concentration (0.001M). Compound S.A binds compound G, but its binding does not completely break the self-association of compound G. Compound S.M, binds compounds A,U,C,G very weakly.
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